We are recruiting for multiple positions at the CSTL! Check out our current positions here

The Center for Cytokine Storm Treatment & Laboratory (CSTL) [pronounced “Castle”] is dedicated to investigating hyperinflammation and immune system dysregulation in the context of human disease. To gain insight into these types of disorders, our group conducts research with the goal of improving the diagnosis, treatment, and management of Castleman Disease, a rare hyperinflammatory disorder. Our group is unique in that instead of focusing on one experimental technique, or subfield, our lab uses multiple techniques and technologies to study Castleman disease (and other hyperinflammatory disorders) from multiple angles. To fulfill this goal, the CSTL recruits scientists with diverse backgrounds and expertise, including basic bench research, biobanking, and data analysis. 

Our interests include:

• Elucidating the etiology, dysregulated cell types, signaling pathways, and effector cytokines in idiopathic multicentric Castleman disease (iMCD) and related cytokine storm disorders

• Identifying effective treatments for iMCD patients

• PI3K/Akt/mTOR signaling in iMCD

• Understanding the role of stromal cells and chemokines in iMCD.

Our research projects are divided into five broad categories:

1. Defining CD and its clinico-pathology

2. Etiology of CD

3. Pathophysiology

4. Treatment effectiveness studies

5. Rare-disease sample acquisition methodologies